发高分文章，无支原体是前提！汉恒助力客户发表Cell Res

8YUE28RI，DALIANYIKEDAXUEZHONGLIUZHONGXINZHUREN、ZHONGLIUGANXIBAOYANJIUYUANYUANZHANGLIUQIANGJIAOSHOUYANJIUTUANDUIZAInatureZIKANCell Research（IF=20.507）SHANGFABIAOLUNZHU，WENZHANGBIAOTIWEI《Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells》，GAIYANJIUZHENGMINGDROSHAYUβ-CateninXIANGHUZUOYONG，JIHUOGANXINGJIYINSTC1，CONGERYOUZHUYUWEICHIRUXIANAIGANXIBAOYANGXIBAO（BCSC）DETEXING，ERAIJIYINAURKACUJINLEDROSHA mRNADE m6AXIUSHIBINGZENGQIANGLEQIWENDINGXING。

 

  ZHIDEYITIDESHI :

" HANHENGSHENGWUDEKANGZHIYUANTISHIJIanti-mycoplasma reagent SaveIt (Hanbio, HB-SV1000)BANGZHUTAWANCHENGLEZHIYUANTIWURANDEJIANCEHEQINGCHUGONGZUO."

 

XIAMIANJIUYIQILAIXIANGXILEJIEYIXIAZHEIPIANWENZHANGDENEIRONG~

 

 

BEIJINGJIESHAO

 

GENJU RNase III XINGDANBAIDEJIEGOUYUZUFEN，KEYIJIANGQIFENCHENGSANLEI；ERDROSHASHIDIERLEIRNase III XINGMEI。YIYOUYANJIUBIAOMINGYOUJIYINZUZHUANLUCHUDEQIANTImiRNA(pre-miRNA)ZAIXIBAOHENEIYOUDROSHAMEIJINXINGCHULI，CHENGWEIJUBEIJINGHUANJIEGOUDEpri-miRNA，ZAIExiportin-5DANBAIDEZHUANYUNZUOYONGXIACONGXIBAOHEZHUANYIZHIXIBAOZHIZHONG。DROSHAHAIKETONGGUOZHUANLUHOUKONGZHIRNAWENDINGXING，KEBIANJIANJIE，3'-MODUANJIAGONGHEZHUANLUZHONGZHIDENGDUOZHONGFANGSHIZHIJIEDIAOJIEZHENGGEZHUANLUZUDEGEZHONGRNADAIXIE。ZUIJINDEYANJIUFAXIAN，DROSHAZAIZHONGLIUZUZHIZHONGPUBIANGAOBIAODAQIEYUZHONGLIUDEBULIANGYUHOUXIANGGUAN，RANER，DROSHASHIRUHECUJINZHONGLIUFAZHANDEQIANZAIDEJIZHIHAIBUTAIQINGCHU。

 

 

SHIYANJIEGUO

 

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ROSHAYUβ-CateninXIANGHUZUOYONGJIHUOGANXINGJIYINSTC1，WEICHIRUXIANAIGANXIBAOYANGXIBAO（BCSC）TEXING

 

YANJIUZHESHOUXIANJIANCELEDROSHAZAIBCSCWEIHUZHONGDEZUOYONG，FAXIANBCSCZHONGDROSHADEmRNAHEDANBAISHUIPINGDOUYOUSUOSHANGDIAO；JINJIEZHEZUOLEDROSHAQIAODIHOUDEJIYINCHAYIXINGBIAODAFENXIHEGANXINGJIYINFENXI，FAXIANGRB10, SLCO4A1,SORBS2, STC1ZHEI4GEJIYINYOUXIANZHUXINGCHAYI，ZAITONGGUORT-qPCRJIANCEYEYANZHENGLEZHEIYIFENXIJIEGUO。ZUIHOU，FENBIEDIAODIZHEIJIGEJIYINFAXIANZHIYOU STC1 NENGGOUYINGXIANGALDH +YAQUNXIBAODESHULIANG，BIAOMINGSTC1DUIDROSHADIAOKONGDEBCSCsZHIGUANZHONGYAO。

 

 

 

 

 

ZAISHENRUYANJIUFAXIAN，STC1DEGUOBIAODAYOULIYUDROSHAQIAODIDERUXIANAIXIBAOALDH +YAQUNXIBAODEXINGCHENG，HUIFULEXIBAOQIUXINGDEXINGCHENGNENGLI，YEZENGJIALEDROSHAQIAODIXIBAOZHONGQIUXINGXIBAODEZHIJINGHESHULIANG；JIANGDROSHA QIAODIDEXIBAOHUODROSHA QIAODIDANSTC1GUOBIAODADEXIBAOZHURUXIAOSHUZHONGFAXIANJIEZHONGDROSHAQIAODIXIBAODESTC1GUOBIAODADEXIAOSHUBIZHUSHEDROSHAQIAODIXIBAODEXIAOSHUXINGCHENGGENGDADEZHONGLIU。